BASS seminar: Dr. Raj Loganathan
Coordinate Transcriptional Regulation of Cell Shape
and Size during Tubulogenesis
Dr. Rajprasad Loganathan
Johns Hopkins University Department of Cell Biology
Shape and size changes, from the level of cells through the level of organisms, are highly intertwined. In embryos, cell size and shape changes during the formation of tissues need to be coordinated to yield organs for optimal form and function. This coordination is critical for tubular tissues and organs since shape and size determine their efficacy to secrete, absorb, store, transport, and exchange fluids so vital for metazoan physiology. The mechanisms for achieving such high degrees of size-shape, i.e., growth-form, coordination at the cellular level are poorly understood. In the Drosophila embryonic salivary gland—an exemplary model system for the study of tubulogenesis—a potential regulatory mechanism orchestrating cell growth-form coordination at the level of gene transcription was recently uncovered by studying Ribbon, a BTB-domain nuclear factor. In this seminar, I will present data suggesting the possibility that Ribbon coordinately regulates cell shape and size during salivary gland tubulogenesis, and I will also highlight the significance of this finding in the context of developmental physiology of tubulogenesis.
Sponsored by the Biology Department in coordination with EPACC
Wednesday, February 19 at 5:30pm to 6:30pm